Precision Filling:

Maintaining precise dosing accuracy with high repeatability presents major challenges for liquid fillers – especially when operating centrifugal or rotary lobe pumps for lower volume products such as vials, single doses and indictable.

Precision liquid filling is crucial for product integrity, and high repeatability ensures production schedules can be precisely set and met.

Masterflex® peristaltic pumps from Barnant are highly-suited for pharmaceutical liquid filling applications – from bench top fillers to large-scale automatic systems.

Unlike many pump designs, Master flex pumps easily maintain a precise, constant flow rate with excellent repeatability.

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High Purity Processes:

Masterflex® "Clean Pump" Technology

Besides requiring precise liquid metering, dosing and transfer, virtually all pharmaceutical and biotechnology research, development and production processes demand sterility, fluid isolation, and zero contamination potential to assure a high level of process and product security.

The FDA also has significant concerns regarding contamination, including cross contamination of biotech products that could potentially alter the safety, identity, strength, quality, or purity of the product. Validation cleaning processes are required and often time-consuming and costly.
 

Sterile liquid flow is paramount in pharmaceutical and bioprocess applications, which is why Barnant's Masterflex® peristaltic pumps are highly-suited for these demanding processes.

Whether it be pharmaceutical products, live cell cultures, nutrients, or bioreactor constituents, our validation-friendly, non-contaminating peristaltic pump systems are designed to ensure precise, sterile control and management of flow while providing longer process run periods and reduced downtime all which translates to process optimization.
 

Tubing Selection:

To maximize the pumping efficiency of viscous fluid, follow these steps.

1. Slow down the speed of your pump. Increasing the speed beyond a certain point will not have any effect on flow rate. The maximum efficient speed of the pump decreases as viscosity increases and tubing size decreases.

2. Choose a larger size tubing than required to pump water. The table below will help you choose the best size.

3. Choose a firm tubing such as Norprene®, PharMed®, Viton®, or Tygon® LFL. Performance will be better because the tubing returns to its original shape quickly after pump head occlusion. For L/S® and I/P® sizes, choose High-performance precision tubing—the thicker wall also returns more quickly to its original shape than Precision tubing. The quicker return allows liquid to be pulled into the tubing with greater force.

4. Select a tubing with a smooth bore. A smooth bore will decrease frictional forces. Tygon®, Tygon® LFL, silicone, or Tygon® silicone formulation are good choices.
5. Decrease the viscosity of your fluid. Heat your fluid if possible; viscosity usually decreases with temperature.

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Accucal® Flowmeters:

Mount these flowmeters on a panel or base. Flow meter base GF-4001 shown.
• Correlated and direct reading all in one easy-to-read meter.
• Accuracy up to ±2% of reading!
• Interchangeable scales—customize your application.
• Extremely low pressure drops—ideal for procedures with critical pressure values .

Correlated and Direct Reading in one easy to use flow meter. Each meter includes correlation charts for air and water and two direct-reading scales—an air scale and a water scale. Easily change between correlated and direct-reading scales depending on your application. Meters are available in 65mm and 150mm scale lengths.

Each direct-reading scale indicates flow rates in metric and English units, for both glass and stainless steel floats under standard operating conditions. Use the new GF-4000 software to create your own custom scales.

Excellent Accuracy is achieved with our second-generation correlation techniques and the factory calibration of the tube. Accuracy can be expressed as a percent of reading—not of full-scale! With correlated use, accuracy is ±2% of reading or ±1% scale division, whichever is greater. With direct-reading use, ±2 divisions accuracy is ±5% of reading or ±3 mm on scale, whichever is greater. All flow tubes have serial numbers for traceability to calibration, accuracy, and manufacturing data.

Quality Industrial Design ensures use in most tough applications. The clear polycarbonate front shield provides a 90° view of the scales on the stainless meters.

Meters are designed for easy flow tube exchange or replacement. The end stop has a large diameter to let you center the flow tube quickly and more accurately than most flow meters. All flow tubes are interchangeable within the same frame size. Call our Application Specialist to order a replacement flow tube or to upgrade your unit.

Mount flow meters on a panel or on our flow meter base (see below). Invert frame for vacuum applications or when back pressure compensation is required.

Advanced Metering Valves are available with GILMONT® flow meters. The shallow taper design gives you linear control over 80% of the usable range. Valves are 14-turn.
 

Ideal for routine plant quality control checks and research laboratory applications

Falling ball viscometers

This viscometer is extremely easy to use; First fill tube with sample, then invert tube, allowing the ball to enter the PTFE screw. Next, restore tube to normal position. Finally fill tube with sample, then invert tube, allowing the ball to enter the PTFE screw. Next, restore tube to normal position. Finally, turn the knob to release the ball, and measure the time of descent. Reading the viscometer is easy—the ball moves against a white background with red reference lines.

Repeatability with good technique varies from ±0.2 to ±1.0%, depending upon time of descent. To time falling ball, order stopwatch/clock on page 1207. Viscometers require a 7 ml sample volume.

Each viscometer is supplied with one glass and one 316 stainless steel high-precision ball. For higher viscosity ranges, use the optional tantalum ball (order separately).

Viscometers are made of precision-bore glass tubing with stabilizing beads. The ball-release device is sealed with a Viton® O-ring.

Note: PTFE O-rings are available for use with liquids that adhere to vinton; call our Application Specialists for more information. Corrosion-resistant DELRIN® makes up the other plastic viscometer parts.